Elderly patients may react to barbiturates with marked excitement, depression, and confusion. Sopra some persons, barbiturates repeatedly produce excitement rather than depression. Dosage should be reduced Per the elderly because these patients may be more sensitive to barbiturates.
Slow IV injection is essential, and patients should be carefully observed during administration. This requires that blood pressure, respiration, and cardiac function be maintained, vital signs be recorded, and equipment for resuscitation and artificial ventilation be available. The rate of IV injection should not exceed 50 mg/min for pentobarbital sodium.
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Has been used for routine sedation. However, barbiturates used infrequently for this indication since there are few clinical situations Per which oral barbiturates provide a safety or efficacy advantage over nonbarbiturate sedatives/hypnotics.
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Pretreatment with or concurrent administration of phenobarbital may decrease the effect of estradiol by increasing its metabolism.
This effect is fully reversible unless hypoxic damage occurs. Consideration should be given to the possibility of barbiturate intoxication even Durante situations that appear to involve trauma.
If you have an allergy to pentobarbital or any other part of pentobarbital. If you are allergic to pentobarbital; any part of pentobarbital; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have ever had porphyria. If you have liver disease. This is not a list of all drugs or health problems that interact with pentobarbital.
Pentobarbital is not used widely Durante clinical medicine because of its poor safety more info profile, habituation, and lack of an antidote. All prescribing clinicians should be aware of the drug's toxicity and adverse event profile. Neurologists can use pentobarbital for refractory status epilepticus.
The excretion of unmetabolized barbiturate is one feature that distinguishes the long-acting category from those belonging to other categories which are almost entirely metabolized. The inactive metabolites of the barbiturates are excreted here as conjugates of glucuronic acid.
The American Society of Health-System Pharmacists, Inc. represents that the information provided Sopra the accompanying monograph was formulated with a reasonable modello of care, and Per conformity with professional standards Con the field. Readers are advised that decisions regarding use of drugs are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and that the information contained Sopra the monograph is provided for informational purposes only.
MAOI prolong the effects of barbiturates probably because metabolism of the barbiturate is inhibited.
Use with caution; should not be used Per mezzo di patients with marked hepatic impairment, including patients more info with premonitory signs of hepatic coma.
Based on comparisons across species, the window of vulnerability to these changes is believed to correlate with exposures Durante the third trimester of gestation through the first several months of life, but may extend out to approximately 3 years of age Durante humans.